A Sticking Point
Kenn
What's more, while a PS/2 mouse retained control through almost any situation (like those times Windows freezes, but the mouse is still perfectly happy to move around the screen), USB mice (and any other USB peripheral) tend to chunk up and become unresponsive in certain situations. In instances of heavy disk or CD-ROM access (for example, when a CD-ROM is inserted into the drive, or CD-audio tracks switch), the mouse would lock up momentarily, not a serious problem for most people, but definitely tarnishing the silver to USB's name. USB's bandwidth-limited nature also poses a future problem - with high-bandwidth peripherals starting to appear such as joysticks, speakers, and scanners, which can take up a good chunk of the bus's 12Mbp pipeline, make it a poor choice for multiple demanding peripherals. Running a next-generation game, while using USB speakers, a USB mouse, while streaming the game's CD Audio has the potential to be a giant nightmare.
Thresh
I personally didn't notice any of these so-called "problems" until you mentioned them, and even now, they are barely noticeable. Unless you can't spare a couple of seconds from your day (generally while your CPU is busy anyway, such as when you first boot up the computer or when you first put in a CD), then it really won't affect you. From a die-hard gamer's point of view, the poor sampling rate of the mouse is the greatest obstacle to the nirvana of first-person-games -- perfectly smooth gameplay. Though the pace at which game developers can churn out next-generation, hardware-breaking games will always outrun the rate of hardware advancement, now and then something new pops up and evens the score a bit.
Advanced Quake (WinQuake, GLQuake, and QuakeWorld) and Quake II players have always had a question lingering in the back of their minds - why does my screen chop so much when I turn the mouse? I ran a few informal tests when I first got my Voodoo2 to verify this - first by rotating my view steadily with the mouse, and then by pressing the left arrow on the keyboard to do the same. Not surprisingly, using the arrow key was smoother than a baby's butt, proving to me that for one, the Voodoo2 wasn't the culprit, and two, that the standard mouse left much to be desired. Completely unrelated to the choppiness problem, I began using Logitech drivers with my MS mouse to make use of Mouseware's acceleration features, which weren't available in Microsoft's drivers. Interestingly enough, I noticed a slight improvement in the sampling rate from switching drivers, which proved to me that the problem was in the software. It was at around this time that the USB Intellimouse came out, and when I saw the benefits of its incredible 125Hz sampling rate, I immediately jumped ship and switched to USB.